Zimulti (Rimonabant)

Food and Drug Administration (FDA) has “Banned weight loss drug Rimonabant 20mg” the use of weight loss pill ‘Rimonabant’ after research showed that the drug caused serious psychiatric side effects, including suicidal tendencies among users. Rimanobant is a patented drug from pharma giant Sanofi Aventis and is sold under various names like Slimona, Acomplia, Monaslim, Bethin, Riobant, Rimoslim or Zimulti. Some of the company’s manufacturing the drug are Ranbaxy, Sun Pharma, Zydus Cadila and Torrent Pharmaceuticals among others. The Rimonabant (Generic Acomplia) manufacturing companies like Zydus Cadila (Slimona/Rioslim), Sun Pharma (Riobant) and other pharmaceuticals has been asked to Stop Manufacturing the weightloss drug Rimonabant 20mg and recall the available products from the market. The drug Acomplia (Rimonabant 20mg) has been under a cloud in Europe and the US, and was Not approved by the US FDA for use in the United States, though it was licensed for general use in Britain and other European countries.

Zimulti (Rimonabant) is an anti-obesity drug. It was approved for marketing as Generic Zimulti in the European Union in June 2006. Generic Zimulti is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. Sanofi argues that Generic Zimulti can also prevent the risk of cardiovascular disease. Generic Zimulti (Rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 receptor Blockers (CB1). Generic Zimulti is used in the treatment of obesity and related conditions. This wonder pill selectively blocks some receptors in the Endocannabinoid system, thus creating a better balance which in turn suppresses appetite and crave to overeat.

Brand Name: Zimulti

Generic Name: Rimonabant

Manufacture By: Zydus Cadila Limited. (Zydus Cadila manufacturing strengths have established it as a producer of world-class generics, branded generics and a major supplier of its range of Active Pharmaceutical Ingredients World-Wide.)

Generic Zimulti is available as 20 mg tablet form.

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Prescription Required: No

Drug Uses
Generic Zimulti (Rimonabant) is used complementary to diet and exercise to treat obesity or overweight patients who suffer from Type 2 diabetes and high levels of fat in the blood. Generic Zimulti can also prevent the risk of cardiovascular disease. Patients with large waist circumference (88 cm in women and 102 cm in men) will mostly benefit from taking Generic Zimulti.

How thw Diet Pill Rimonabant Zimulti Drug work (Class and Mechanism)?

Diet pill Rimonabant Zimulti the weight loss pill contains Rimonabant which is a selective endocannabinoid CB1 receptor antagonist that inhibits the phararmacological effects of cannabinoid agonists in vivo and invitro. The endocannabinoid system regulats energy homeostasis through G-protein coupled cannabinod -1 receptors locatedin the central nervous system and in various peripheral tissues, including adipose tissue (fatty tissue), muscle, the gastrointestinal tract and the liver. While peripheral cannabinoid-1 receptor activation decreases adiponactin production in adipocytes, central cannabinoid-1 receptor activation stimulates hepatic and adipose tissue lipogenic pathways in obese people. Rimonabant Zimulti the weight loss drug is a selective cannabinoid-1 receptor blocker, which reduces overactivation of the central and peripheral endocannabinoid system and prevents weight gain and associated metabolic disorder in genetic and diet-induced obesity, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders. Rimonabant Zimulti the weight loss drug is metabolized by both CYP3A and amidohydrolase (predominantly hepatic ) pathways in vitro. Rimonabant Zimulti the weight loss drug is mainly eliminated by metabolism and subsequent biliary excretion of metabolites.only 3% of the dose of rimonadant is eliminated in the urine, while approximately 86% of the dose is excreted in the faeces as unchanged drug and metabolites.
In clinical studies, Rimonabant Zimulti the weight loss drug has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss. Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Rimonabant Zimulti the weight loss drug 20mg was beyond that expected from weight loss alone.

How Taken

• In adult, the recommended dosage of Rimonabant Zimulti the weight loss drug is one tablet of 20 mg once daily to be taken in the morning before breakfast. The treatment should be introduced with mildly reduced calorie diet.
• Do not crush or chew the tablet swallow the whole Diet pill Rimonabant Zimulti.
• Diet pill Rimonabant Zimulti should be used with caution in patients over 75 years of age.
• Diet pill Rimonabant Zimulti tablets are not recommended for children below the age of 18 years.

Missed Dose
Take the missed dose of Diet pill Rimonabant Zimulti as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of Diet pill Rimonabant Zimulti to make up for a missed one.

NOTE: It takes 2 hours with a single dose of Diet pill Rimonabant Zimulti to achieve the maximum plasma concentration (the amount of drug require in body for action) and a steady state (the concentration of a drug require in a body for a desired effect) in 13 days and in case of obese patient (BMI more than 30) a steady state is 25 days so do not miss the dose try to take Rimonabant atleast for 25 days for desired result.

Storage
Diet pill Rimonabant Zimulti weight loss pills should be stored at room temperature in a cool and dry place. Keep away from the reach of children.

What are the Warnings / Precautions of Diet pill Rimonabant Zimulti weight loss pills?

It is advisable to consult a doctor before taking Diet pill Rimonabant Zimulti weight loss pills and adhere to the prescribed dosage to attain the expected results. Diet pill Rimonabant Zimulti weight loss pills should not be taken by pregnant woman since it may cause birth defects in an unborn baby. Diet pill Rimonabant Zimulti weight loss pills should not also be used by lactating mothers. Though not clinically proved, there is possibility that this diet pill may be passed into breast milk. Diet pill Rimonabant Zimulti weight loss pills is metabolized by the liver, so it is recommended that patients with moderate hepatic impairment should consult their healthcare provider before using the drug.

Possible Side Effects of Diet pill Rimonabant Zimulti weight loss pills?
As your body adjusts to the Diet pill Rimonabant Zimulti weight loss pills, you may experience some of the reported side effects like anxiety, insomnia, nausea, headache, hallucinations, disorientation, hypertension, heart and kidney damage, palpitations, heart attack, strokes, psychosis, fatigue and hyperphagia (excessive eating beyond normal feeling of hunger), gastrointestinal discomfort and dizziness.

More Information about Diet pill Rimonabant Zimulti weight loss pills?

• Diet pill Rimonabant Zimulti weight loss pills has been marketed successfully in 43 countries worldwide (the European Union, Denmark, Finland, Germany and U.K.)
• Diet pill Rimonabant Zimulti weight loss pills has been studied as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking.