Doxycycline is a semi-synthetic tetracycline broad spectrum antibiotic invented and clinicallydeveloped in the early 1960s by Pfizer Inc. Doxycycline is a tetracycline broad spectrum antibiotic which acts against both gram positive and gram negative organisms. Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow.
Vibramycin (Doxycycline) - Periostat (Doxycycline) is most commnly used for eliminating bacteria that cause infections, such as urinary tractinfections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), including pneumonia, Lyme disease, acne, and venereal (sexually transmitted) disease. Doxycycline is used in some areas for the treatment of Chloroquine-resistant falciparum malaria
Brand Name: Vibramycin - Periostat
Generic Name: Doxycycline
Manufacture By: U.S.V Laboratories Limited (U.S.V Laboratories Limited manufacturing strengths have established it as a producer of world-class generics, branded generics and a major supplier of its range of Active Pharmaceutical Ingredients World-Wide).
Vibramycin (Doxycycline) - Periostat (Doxycycline) is available as 100mg tablet form.
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Prescription Required: No
Why is Vibramycin (Doxycycline) - Periostat (Doxycycline) prescribed?
Vibramycin (Doxycycline) - Periostat (Doxycycline) is a broad-spectrum antibiotic, belongs to tetracyclines group, is commonly used for the treatment of bacterial infections, leptospirosis, toxoplasmosis, mycoplasma, psittacosis, and many diseases carried by ticks including Lyme disease, ehrlichiosis, Rocky Mountain spotted fever, and salmon poisoning. Syphilis , Lympho granuloma veneram , Typhus fever , Respiratory tract infections, Prophylaxis of malaria , Urinogenital tract infections, Trachoma, Pelvic inflammatory diseases, Acne, Diarrhoea, Gonorrhea in penicillin allergic individuals, Pneumonia, Rickettsial infections, Urethritis, Anthrax.
Vibramycin (Doxycycline) - Periostat (Doxycycline) is also used for the following indications as follows:
- Borrelia burgdorferi (agent of Lyme disease);
- Mycoplasma species (in upper respiratory and urinary infections).
- Chlamydia psittaci (an agent of feline upper respiratory infection);
- Ehrlichia species (a tick-borne organism);
- Haemobartonella felis (agent of feline infectious anemia);
- The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.
How Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug works (Drug Class and Mechanism)?
Doxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome. Doxycycline is used in some areas for the treatment of Chloroquine-resistant falciparum malaria.
Absorption: Orally well absorbed, food has not much effect on absorption. Distribution: Widely distributed; shows protein- binding. Metabolism: Not substantially metabolized inside the body. Excretion: Primarily excreted through faeces. Some drug is present in breast milk & a portion is excreted through urine.
How Taken Dosage:
- Adults: 0.2gm initial dose followed by 0.1gm once daily.
- In severe infections: 0.1gm 12 hourly up to 10 days.
- Malaria: 200 mg daily for at least 7 days after treatment with quinine.
- Malaria prophylaxis: Doxycycline 100 mg daily.
- Anthrax: 200 mg / day in 2 divided doses
- Acne: 100mg/day or 50mg twice daily.
- Urethritis: 100 mg twice a day for 7 days Children (above 8 years of age): 3 to 5 mg/kg/day in two divided doses.
Missed Dose?
If you miss to give a dose of Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug, give it as soon as possible. If it is almost time for your pet to take the next dose, skip the dose and go back to the regular dosing schedule. Do not double the dose to catch up.
Storage
Store Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug between 39 and 86 degrees F (4 and 30 degrees C). Keep Vibramycin out of the reach of children and away from pets.
Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug Warnings / Precautions?
- Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby.
- Do not take this medication without telling your doctor if you are breast-feeding a baby.
- Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).
- Before taking doxycycline, tell your doctor if you have liver or kidney disease.
- Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug should not be used in animals with known hypersensitivity or allergy to the drug.
- Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with doxycycline. Such drugs include certain antacids, iron supplements, kaolin, bismuth subsalicylate and certain antibiotics.
- Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug should not be administered orally with calcium or calcium-containing medications because they may inhibit oral absorption of the antibiotic.
- Do not use this medication if you are pregnant. It could cause harm to the unborn baby, including permanent discoloration of the teeth later in life.
- Doxycycline can make birth control pills less effective. Use a second method of birth control while you are taking doxycycline to keep from getting pregnant.
- You may not be able to take doxycycline, or you may need a dose adjustment or special tests during treatment.
- Do not give doxycycline to a child younger than 8 years old.
- Do not take any doxycycline after the expiration date printed on the bottle. Expired doxycycline can cause a dangerous syndrome resulting in damage to the kidneys.
Possible Side Effects of Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug?
- Occasionally vomiting has been observed, especially when high doses are administered.
- severe headache, dizziness, blurred vision; fever, chills, body aches, flu symptoms; severe blistering, peeling, and red skin rash; urinating less than usual or not at all; pale or yellowed skin, dark colored urine, fever, confusion or weakness; severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; loss of appetite, jaundice (yellowing of the skin or eyes); or Unusual weakness, Easy bruising or bleeding,.
Possible Drug interactions with Doxycycline:
• Antacids (aluminium, calcium zinc, and magnesium), Iron salts,
• Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy.
• Anticoagulants: Increase the hypothrombinemic effects of anticoagulants.
• Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
• Digoxin: Increased serum levels leading to digoxin toxicity.
• Methoxyflurane: Nephrotoxic effects of both increased.
• Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
• Penicillins: Efficacy reduced.
• Food: Dairy products decrease efficacy of tetracyclines.
More Information on Vibramycin (Doxycycline) - Periostat (Doxycycline) Drug?
• Generally, children under 8 years old and women in the last half of pregnancy should not take Vibramycin. It may cause developing teeth to become permanently discolored. (However, children under 8 may be given Vibramycin for inhalational anthrax.).
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