Generic Celebrex (Celecoxib) is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It is a member of a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) called COX-2 inhibitors. Generic Celebrex is used for treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual pain, or pain. It is used in familial adenomatous polyposis (FAP) to decrease the number of polyps (growths) in the rectal area (colonic polyps). Generic Celebrex (Celecoxib) works by reducing hormones that cause inflammation and pain in the body. Generic Celebrex (Celecoxib) is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis.
Brand Name: Celebrex
Generic Name: Celecoxib
Manufacture By:
Generic Celebrex (Celecoxib)is manufactured by Zydus Cadila, IPCA Laboratories, Dr. Reddy`s Laboratories Ltd.
Available in 100 mg and 200 mg capsule form.
Zydus Cadila, IPCA Laboratories,Dr.Reddy`s Laboratories Ltd. manufacturing strengths have established it as a producer of world-class generics, branded generics and a major supplier of its range of Active Pharmaceutical Ingredients world-wide.
Our online medical store supplies only top-quality generic drugs that are exact equivalent of the brand name drugs.
Prescription Required: No
Drug Uses
Celecoxib is used for the relief of pain,fever,swelling, and tenderness caused by osteoarthritis,rheumatoid arthritis,and ankylosing spondylitis.Celecoxib does not prevent the progression of either type of arthritis.It reduces only the
Symptoms and signs of arthritis.Celecoxib has been approved for patients with familial FAP who have not had their colons removed. Generic Celebrex also is approved for the relief of acute pain and the pain of menstrual cramps (primary dysmenorrhea).
Drug Class and Mechanism
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes the pain, fever, swelling and tenderness. Celecoxib blocks prostaglandin synthesis peripherally by selective noncompetitive inhibition of cyclooxygenase-2 (COX-2) enzyme resulting in lower concentrations of prostaglandins.As a consequence,inflammation and its accompanying pain, fever, swelling and tenderness are reduced. This results its anti-inflammatory action. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood. NSAIDs have been found to prevent the formation and reduce the size of polyps in patients with the genetic disease,familial adenomatous polyposis (FAP). In FAP, patients develop large numbers of polyps in their colons, and the polyps invariably become malignant.The only cure of FAP requires removal of the entire colon. Celecoxib is approved as an adjunctive (secondary) treatment among patients with FAP. The cramping and pain during menstrual periods is due to prostaglandins, and blocking the production of prostaglandins with celecoxib reduces the cramps and pain.
Absorption: Rapidly absorbed after oral administration Distribution: Celecoxib widely distributed in the body.97% bound to the plasma proteins. Metabolism: Celecoxib metabolized in the liver to its metabolites Excretion- Excreted through urine and faeces.
How Taken
For Osteoarthritis: the dose usually is 100 mg twice daily or 200 mg as a single dose.
For Rheumatoid Arthritis: the dose usually is 100 or 200 mg twice daily.
For acute pain or menstrual cramps: the dose is 400 mg as a single dose on the first day, followed by an additional 200 mg if needed, then 200mg twice daily as needed.
For FAP: the recommended dose is 400 mg twice daily.
Take celecoxib with food or milk to lessen stomach upset. Do not crush,chew, break, or open an extended-release capsule. Swallow the whole pill.
Missed Dose
Take the missed dose as soon as you remember.Since celecoxib is sometimes taken only as needed,you may not be on a dosing schedule.If it is almost time for your next dose,wait until then to take the medicine and skip the missed dose.Do not take extra medicine to make up the missed dose.
Storage
Store in a dry place below 30 degree C. Keep out of reach of children.
Warnings/Precautions
Concomitant use of celecoxib with aspirin or other NSAIDs (e.g., ibuprofen, naproxen, etc.) may increase the occurrence of stomach and intestinal ulcers.
Fluconazole (Diflucan) increases the concentration of celecoxib in the body by inhibiting the breakdown of celecoxib in the liver. Therefore, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are taking fluconazole.
Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%. Therefore, lithium therapy should be closely monitored during and after therapy with celecoxib.
Persons, taking the anticoagulant (blood thinner) warfarin (Coumadin), should have their blood tested when initiating or changing celecoxib treatment, particularly in the first few days, for any changes in the effects of the anticoagulant.
Do not drink alcohol while taking celecoxib. Alcohol can increase the risk of stomach bleeding caused by celecoxib.
This medication may be harmful to an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Taking celecoxib during the last 3 months of pregnancy may result in birth defects.
Do not take Generic Celebrex (celecoxib) during pregnancy unless your doctor has told you to.
Celecoxib passes into breast milk and may affect a nursing baby.
Do not take celecoxib without first talking to your doctor if you are breast-feeding a baby.
Do not give Generic Celebrex (Celecoxib) to a child younger than 2 years old without the advice of a doctor.
Possible Side Effects
Individuals who have developed allergic reactions (rash,itching,difficulty breathing) from sulfonamides (e.g., Bactrim),aspirin or
NSAIDs may experience an allergic reaction to celecoxib and should not take celecoxib.
Although stomach and intestinal ulcers occur with the use of celecoxib,their incidence is less than with other NSAIDs in short-term studies.
The most common adverse effects are headache, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia.
Other side effects include fainting, heart failure, aggravation of hypertension, chest pain, kidney failure, , ringing in the ears, deafness, stomach and intestinal ulcers, bleeding, blurred vision, anxiety, photosensitivity, weight gain, water retention, flu-like symptoms, drowsiness and weakness. Allergic reactions can occur with celecoxib.
More Information
If you experience any of the following serious side effects, stop taking celecoxib and seek medical treatment or call your doctor immediately:
An allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
Other, less serious side effects may be more likely to occur.
Continue to take celecoxib and talk to your doctor if you experience flatulence or diarrhea; dizziness; headache; or insomnia.
Side effects, other than those listed here, may also occur. Talk to your doctor about any side effect that seems unusual.